Polidocanol

  • Hydroxypolyethoxydodecan
  • Macrogol
  • Lauromacrogol 400 ( Ph. Eur )
  • Laureth -9 ( INCI)
  • 3055-99-0

C05BB02

Semi-solid white to almost white substance above the melting point: yellowish liquid

Local anesthetic

0.98 g · cm -3

20-21 ° C

Miscible with water

2000 mg · kg -1 ( LD50, rat, oral)

Template: Infobox chemical / molecular formula search available

Polidocanol (trade name Thesit ® ) is a surface-active substance with a oberflächenbetäubenden effect. Polidocanol is used as a drug, as a pharmaceutical excipient and as a cosmetic Inhaltststoff.

Medicinally polidocanol is externally effective in itching, or mild pain, also it is used for sclerotherapy of varicose veins ( varices ), spider veins and hemorrhoids, to which it is injected into the appropriate tissue.

Physico-chemical properties

Polidocanol is a polyalkylene glycol ethers. Polidocanol used medicinally ( lauromacrogol 400) is by definition of the European Pharmacopoeia 6.0, " a mixture of ethers of various Macrogols with fatty alcohols, mainly lauryl alcohol. " Mean fatty alkyl chain length is 10 to 14 carbon atoms; the average number of oxyethylene units is from 7 to 11, corresponding to a relative molecular weight of 400 for the polyoxyethylene portion.

Due to the lipophilic and the hydrophilic dodecyl ether chain results in a good miscibility with water, oil and other solvents. In addition, polidocanol has surface-active properties as a good wetting and thus a rapid cleaning power.

Therapeutic Areas of application

In three to five percent concentration polidocanol is used for pain and itch relief in dermatological formulations ( ointments, creams or gels ), such as eczema, itchy skin and eczema. It may also be combined with other drugs. Also in finished drug products and medical skin care products ( concentrations up to 3 percent) comes polidocanol used.

For sclerotherapy for spider veins or hemorrhoids polidocanol used in 0.25 to 3 % concentration in ethanolic- aqueous solution that is injected intravenously or submucous. Polidocanol damage the endothelium in this case the blood vessels. After the injection, a compression bandage is applied, wherein the damaged vein walls are pressed together. Thereby a thrombus is inhibited and there is the desired conversion to fibrous tissue, and thus the sclerotherapy.

Finished medicinal product

Aethoxysklerol (D, A, CH), Anaesthesulf (D), Asclera (USA), Recessan (D, A), Sclerovein (CH),

ACOIN (D), Antidry calm (CH), Assan rem ( CH), Balmed Hermal Plus (A, CH), Balneum Hermal Plus ( D), fire and wound gel (D), Dentalgin (A), Dentinox (D, A) Eludril (CH), Lindosan (A), fat Linola -N oil bath ( D), Optiderm (D, A), Pruri -med (CH), Prurimix (A), Solcoseryl (D, A, CH), Sportusal Emgel / spray sine heparino (CH), Venucrem (CH), Vonum (A)

Cosmetic preparations

Hydrolotio sensitive (D), Polaneth Lotion ( D), Hyposens Lotion ( D), Aqueo Lotion ( D)

Polidocanol is up to 4% used in rinse-off products such as shampoos and washing lotions in concentrations as nonionic emulsifier and wetting agents. Because of the short skin contact up to wash a local anesthetic effect is excluded. In leave-on preparations, ie preparations that vebleiben longer on the skin such as skin creams and lotions, polidocanol up to 3% comes in concentrations. Whether such concentrations have a local anesthetic effect, and therefore, at least in the long-term use, are to be regarded as not safe for consumers, is considered controversial.

International Nomenclature of Cosmetic Ingredients CAS registry number PubChem Anatomical Therapeutic Chemical Classification System Dangerous Substances Directive (67/548/EEC) Hydrophile Cutaneous condition
501420
de