Spermidine

• Monoaminopropylputrescin
• 1,5,10 - Triazadecan
• N-(3 -aminopropyl ) butane - 1 ,4-diamine (IUPAC)

Colorless, clear liquid

Liquid

0.93 g · cm -3

22-25 ° C

Risk

Template: Infobox chemical / molecular formula search available

Spermidine, also called Monoaminopropylputrescin, a polyamine, and an intermediate in the formation of putrescine and spermine from decarboxylated S-adenosylmethionine.

Spermidine is present in all living organisms, and is closely related to the cell growth. The exact physiological function of spermidine in growing cells such as in the production of nucleic acids and proteins or membrane stabilization, however, is not yet fully understood. The amount of spermidine in the organism increases at an acceleration of metabolism. In a slowing of the metabolism, the production of spermidine decreases. The concentration of endogenous spermidine also decreases with aging.

Natural conditions that can increase the Spermidinwert are growth, pregnancy, repair of muscle after strenuous physical exertion and regeneration of red blood cells after blood loss or poverty or after longer stays level. Various diseases also be signaled by increased Spermidinwerte, such as chronic inflammation of the joints ( " rheumatoid " ), the liver ( hepatitis), of the intestines (colitis) and the skin ( eczema, psoriasis).

In animal experiments on fruit flies showed that a supply of spermidine by the food at these insects of age-related dementia counteracts. The transferability of these results to humans has not yet been investigated. (Original Article )

Biochemical and physiological effects

• Inhibit neuronal NO synthase ( nNOS, an enzyme which nitrogen monoxide (NO ) was synthesized ).
• Binds and precipitated DNA.
• Stimulates the activity of T4 polynucleotide kinase.