Stauffer syndrome

The Stauffer 's syndrome is a non- metastasis- related liver dysfunction in patients suffering from renal cell carcinoma. It was first described in 1961 by Stauffer. This paraneoplastic syndrome seen in 3-20 % of cases in the sense of an increase of alkaline phosphatase in 67% to prolong the prothrombin time and hypoalbuminemia and at 20 to 30% of cases to increase in indirect bilirubin and the alpha2 - and γ globulins. Fever, weight loss and fatigue are also to be counted. Naturally, liver metastases must be excluded. Bromsulphthalein the test, there is an increased retention.

Histologically, it comes at the Stauffer syndrome in non-specific hepatitis with lymphocytic infiltrate and necrosis. In the liver, leads to an increased production of enzymes. By surgical removal of the primary tumor, in this case through a partial nephrectomy or nephrectomy also Stauffer syndrome can be treated in 60-70 % of cases. Persistence or recurrence of Stauffer 's syndrome is associated with a poor prognosis of the underlying disease or with a tumor recurrence.

The Stauffer syndrome occurs almost exclusively in patients who have the primary tumor in the right kidney.

Very likely responsible for the symptoms triggered by the tumor increased production of interleukin -6 and prostaglandin. The release of these neurotransmitters causes a release of calcium ions by osteoclasts.