Sticky platelet syndrome

The sticky platelet syndrome ( syndrome of adhesive platelets) is a thrombozytäres Hyper aggregation syndrome from the group of hereditary thrombophilia. An exceedingly Reagibiliät of blood platelets, there is a strong clumping ( platelet aggregation ), which an increased risk for vascular occlusion due.

Cause

By the heaped familial occurrence of the syndrome, a genetic cause is assumed to be an autosomal dominant pattern of inheritance. The exact cause is not yet known.

Frequency

The syndrome often occurs in combination with other thrombophilias, about a factor V Leiden mutation or hyperhomocysteinemia. It can often be diagnosed with occlusion of the retinal vessels in the eye in people with deep vein thrombosis, peripheral arterial disease, coronary heart disease, Transient ischemic attack (TIA ) and just over half of all patients.

Diagnostics

The investigation on the sticky platelet syndrome is only possible if the patient is currently not having a platelet aggregation inhibitor such as ASA is treated. If this condition is given, the syndrome ( platelet aggregometry ) can be identified or excluded within the first three and a half to four hours after a blood sample by means of a functional analysis of platelets in the context of a platelet aggregation test. For the diagnosis meaningful is the finding of hyper-reactivity of platelets with disproportionately accelerated maximum aggregation in application of stimulants L- epinephrine and adenosine diphosphate.

Follow

People with the sticky platelet syndrome have an increased risk of venous, arterial, and cerebrovascular occlusions ( thromboembolism ).

Also, there is evidence that angina pectoris can often be traced in angiographically unremarkable coronary arteries on the syndrome.

In the presence of the sticky platelet syndrome may occur during therapy with warfarin for thromboembolic complications, so the treatment must be continued with a combination therapy of warfarin and antiplatelet drugs.

When family planning may lead to impairments such as miscarriage or infertility.

After a kidney transplant can be expected in the presence of the sticky platelet syndrome in patients with an increased risk for graft dysfunction and thromboembolic complications.

Treatment

The sticky platelet syndrome is treated with antiplatelet agents. Is usually in a low dose acetylsalicylic acid (ASA ) is used, which leads to a damping of hyperaggregability, and thus prevents excessive agglomeration.

About a month after starting treatment, a platelet aggregation test should be made ​​to verify the success of treatment and, if appropriate, adjust the dosage of the medication again.

History

The syndrome was first in 1983 from a scientific point of Dr. Eberhard F. Mammen et al. described.