Thialbarbital

• 5 - (1- cyclohex -2-enyl )-5- prop-2- enyl -2 -1 ,3- sulfanyliden diazinan -4 ,6- dione ( IUPAC)
• 5 - (2 -cyclohexen- 1-yl) dihydro- 5-( 2-propenyl )-2- thioxo- (1H, 5H)- pyrimidine -4 ,6- dione
• Kemithal
• Thialpenton

• 467-36-7
• 3546-29-0 (sodium salt )

Sedative

1.2016 g · cm -3 ( 25 ° C)

370 mg · kg -1 ( LD50, Mouse, oral, base)

Template: Infobox chemical / molecular formula search available

Thialbarbital is a short-acting barbiturate with predominantly hypnotic effect. Structurally, it is a barbituric acid derivative, but with a keto oxygen atom is replaced by sulfur ( thiobarbiturate ). In Germany there are no preparations containing the active substance, admitted; earlier it was - as well as its sodium salt - used in veterinary medicine.

Preparation and Properties

The synthesis of Thialbarbital is possible by a condensation reaction of thiourea with Allylcyclohexenmalonsäurediethylester. From the barbiturate are three different polymorphic modifications. In animal studies with mice Thialbarbital showed a moderate toxicity after oral administration; the LD50 was 370 mg / kg body weight.

Legal status

Thialbarbital is not listed in the Federal Republic of Germany in Appendix 3 of the Narcotics Act and does not fall under the international Convention on Psychotropic Substances.