Thioacetamide

• TAA
• Thioessigsäureamid

Colorless, odor of rotten eggs, crystalline solid

Fixed

1.37 g · cm -3

113 ° C.

In water 163 g · l-1

Risk

301 mg · kg -1 ( LD50, rat, oral)

-71.7 KJ / mol

Template: Infobox chemical / molecular formula search available

Thioacetamide is the amide of Thioacetic. It has the molecular formula C2H5NS and is structurally closely related to acetamide.

Use

Upon heating in aqueous solution it decomposes to hydrogen sulfide and ammonium acetate. Therefore, it is used in classical cation separation process as well as in the gravimetric determination of copper for the in situ generation of hydrogen sulfide.

An advantage over the direct use of hydrogen sulfide gas is very convenient dosing and application, the favorable performance of the homogeneous precipitation and especially the fact that must be stored and used no toxic H2S gas.

Thioacetamide itself is toxic and carcinogenic, but good to handle, since it is a solid. In the laboratory, it is usually the better alternative, the much cheaper hydrogen sulfide gas is still employed in the art.

TAA also plays a role as profibrogene substance for the study of fibrosis of organs, especially liver fibrosis and cirrhosis. Here it is used for induction of liver damage in animal models.