Thiouracil

2- thioxo -2 ,3- dihydro-1H- pyrimidin- 4-one

H03BA

Bitter-tasting crystals

Thyreostatikum

Iodisationshemmstoff

> 300 ° C ( decomposition)

• Insoluble in ethanol, diethyl ether and acids, soluble in alkali solutions

Attention

2850 mg · kg -1 ( LD50, mouse, oral)

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Thiouracil is a historically relevant anti-thyroid drug from the group of thionamides. Graves' disease was first treated in 1943 by Edwin B. Astwood using this Thyreostatikums.

Mechanism of action and side effects

It prevents the binding of iodine and thus the formation of thyroid hormone ( triiodothyronine and thyroxine). Its mechanism of action corresponds to that which still applied succession preparations (eg carbimazole and thiamazole ).

Side effects of hypothyroidism and the risk of causing cancer are particularly mentioned in thyroid and liver in overdose. The drug is contraindicated during breast-feeding because it accumulates in the breast milk and may cause a risk to the child.