Tiabendazole

  • 2 - (4 -thiazolyl )-1H -benzimidazole
  • Thiabendazole as active substances
  • Thibenzol
  • E 233 (up to 1998)
  • INS 233 (since 1998)

P02CA02 D01AC06

Colorless solid

Anthelmintic

304-305 ° C

In water <50 mg · l-1 (20 ° C)

Attention

20 mg · m-3

1300 mg · kg -1 ( LD50, mouse, oral)

Template: Infobox chemical / molecular formula search available

Thiabendazole ( TBZ) is a drug from the group of benzimidazoles, which is used as a fungicide and as an anthelmintic ( vermifuge ). Thiabendazole was introduced in 1964 by Merck, Sharp & Dohme.

Use

Agriculture

The substance is used as a systemic fungicide with protective and curative action. As Arbotect it was used against the Dutch elm disease.

In Germany and Austria thiabendazole is currently only approved as a drug in wound closure means for trees.

In Switzerland, thiabendazole may be in addition used for the treatment of seed potatoes. Also, have burned incense in Switzerland greenhouses for the control of gray mold (Botrytis cinerea) with a thiabendazolhaltigen preparation.

Food additive

Thiabendazole was deleted from the list of additives in 1998 and has since performed as a fungicide. Thus, the INS number 233 was from the E number 233 on the use of this changes nothing: it is mixed into the wax with which the peel of citrus fruits and bananas are treated. It is intended to prevent the formation of mold fungi. For citrus, the reference is " preserved with thiabendazole " prescribed, but not for bananas, although the recording when peeling occurs mainly via the hands; often this information is nevertheless made ​​voluntarily. Furthermore, thiabendazole may be contained in extremely small concentrations in fruit juices.

Allowed in Germany and the EU and in citrus fruits and bananas up to 5 mg thiabendazole per kilogram food to be included in onions 15 mg / kg. In fruit juices, the content 0.01 mg · kg -1 may not exceed.

To prevent the molds of citrus fruit, and imazalil, orthophenyl phenol, or biphenyl may be used.

The tobacco law allows the preservation of tobacco sheet with thiabendazole.

Veterinary medicine

In veterinary medicine, thiabendazole is a commonly used anthelmintics, which is mainly used against nematodes. It is administered orally. The mechanism of action is not yet finally resolved.

Toxicology

The mean LD50 in cattle is 700 mg · kg -1 body weight in sheep 1200 mg · kg -1 body weight when administered orally. In similar high doses partially severe liver and kidney damage and deaths were observed in dogs. Symptoms of poisoning with thiabendazole may be palpitations, incoordination, ataxia, excessive salivation and diarrhea.

Overall, the acute toxicity of thiabendazole According to the Federal Institute for Consumer Health Protection and Veterinary Medicine but small. There is no evidence of a carcinogenic, mutagenic or toxic to reproduction in humans.

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