Tioconazole

  • (RS ) -1 - [2 - [(2- chloro-3- thienyl) methoxy] - 2 - (2,4- dichlorophenyl) ethyl] -1H-imidazole
  • Rac-1 -[2 - [(2- chloro-3- thienyl) methoxy] - 2 - (2,4- dichlorophenyl) ethyl] -1H-imidazole
  • DL -1-[ 2 - [ (2- chloro-3- thienyl) methoxy] - 2 - (2,4- dichlorophenyl) ethyl] -1H-imidazole
  • (±) -1 - [2 - [(2- chloro-3- thienyl) methoxy] - 2 - (2,4- dichlorophenyl) ethyl] -1H-imidazole
  • (RS ) -1 - [ 2,4-dichloro- β -[( 2-chloro -3-thienyl ) oxy] phenethyl ] imidazole
  • DL -1-[ 2,4-dichloro- β -[( 2-chloro -3-thienyl ) oxy] phenethyl ] imidazole
  • Rac -1-[ 2,4-dichloro- β -[( 2-chloro -3-thienyl ) oxy] phenethyl ] imidazole
  • (±) -1 - [ 2,4-dichloro- β -[( 2-chloro -3-thienyl ) oxy] phenethyl ] imidazole
  • Tioconazolum

D01AC07 G01AF08

White to off- white crystalline powder

Antifungal

168-170 ° C ( tioconazole · hydrochloride)

Very slightly soluble in water, very slightly soluble in dichloromethane, slightly soluble in ethanol 96 %

Attention

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Tioconazole is a drug used to treat fungal infections of the skin and mucous membranes caused by dermatophytes, yeasts and molds, as well as in pityriasis versicolor and Erythrasma.

Clinical information

Contraindications ( contraindications)

Application to the eye.

Chemistry, isomerism

Tioconazole is a chiral drug and contains a stereocenter. So there are two stereoisomers, the ( R) form and the ( S) form. The commercial preparations containing the drug as a racemate ( 1:1 mixture of (R ) - and ( S)- isomers). (2,4- dichlorophenyl ) -2 - - (1H -imidazol- 1-yl) -ethanol ( an intermediate of miconazole synthesis) is deprotonated with sodium hydride and then with 2-chloro -3-( chloromethyl) for the synthesis is 1 - thiophene implemented.

Trade names

Mykontral (D), Trosyd (A, CH)

776530
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