Tioconazole
- (RS ) -1 - [2 - [(2- chloro-3- thienyl) methoxy] - 2 - (2,4- dichlorophenyl) ethyl] -1H-imidazole
- Rac-1 -[2 - [(2- chloro-3- thienyl) methoxy] - 2 - (2,4- dichlorophenyl) ethyl] -1H-imidazole
- DL -1-[ 2 - [ (2- chloro-3- thienyl) methoxy] - 2 - (2,4- dichlorophenyl) ethyl] -1H-imidazole
- (±) -1 - [2 - [(2- chloro-3- thienyl) methoxy] - 2 - (2,4- dichlorophenyl) ethyl] -1H-imidazole
- (RS ) -1 - [ 2,4-dichloro- β -[( 2-chloro -3-thienyl ) oxy] phenethyl ] imidazole
- DL -1-[ 2,4-dichloro- β -[( 2-chloro -3-thienyl ) oxy] phenethyl ] imidazole
- Rac -1-[ 2,4-dichloro- β -[( 2-chloro -3-thienyl ) oxy] phenethyl ] imidazole
- (±) -1 - [ 2,4-dichloro- β -[( 2-chloro -3-thienyl ) oxy] phenethyl ] imidazole
- Tioconazolum
D01AC07 G01AF08
White to off- white crystalline powder
Antifungal
168-170 ° C ( tioconazole · hydrochloride)
Very slightly soluble in water, very slightly soluble in dichloromethane, slightly soluble in ethanol 96 %
Attention
Template: Infobox chemical / molecular formula search available
Tioconazole is a drug used to treat fungal infections of the skin and mucous membranes caused by dermatophytes, yeasts and molds, as well as in pityriasis versicolor and Erythrasma.
Clinical information
Contraindications ( contraindications)
Application to the eye.
Chemistry, isomerism
Tioconazole is a chiral drug and contains a stereocenter. So there are two stereoisomers, the ( R) form and the ( S) form. The commercial preparations containing the drug as a racemate ( 1:1 mixture of (R ) - and ( S)- isomers). (2,4- dichlorophenyl ) -2 - - (1H -imidazol- 1-yl) -ethanol ( an intermediate of miconazole synthesis) is deprotonated with sodium hydride and then with 2-chloro -3-( chloromethyl) for the synthesis is 1 - thiophene implemented.
Trade names
Mykontral (D), Trosyd (A, CH)