TLR-2

• OMIM: 603028
• UniProt: O60603

The Toll-like receptor 2 (TLR -2 ) is a membrane protein that is a component of the innate immune system of chordates. The receptor is located on the surface of leukocytes and cells of the lung and liver. It can exogenous substances, in particular components of the cell wall of bacteria to recognize and pass corresponding signals to the cell. Mutations in the TLR -2 gene in human can cause susceptibility to leprosy or tuberculosis infections.

The discussed here TLR -2 is a member of a large family of homologous toll-like receptors ( TLR).

Occurrence

TLR-2 is expressed on monocytes, macrophages, dendritic cells, B cells and T cells including Treg. In some cases, this happens as a heterodimer (combined molecule) with, for example, TLR -1 or TLR - sixth TLR -2 is also found in the epithelium of the trachea.

Operation

TLR -2 recognizes as oriented on the surface membrane receptor surface molecules of several types of bacteria, especially leprosy, tuberculosis and Lyme disease pathogen. In many cases, the binding of these molecules leads to the production of many cytokines and enzymes is increased. However, since these pathogens are able to influence the spontaneous cell's own immune defense presented the cell wall molecules, a consistent picture of the TLR -2 normally outgoing signals is still unclear.