Uhthoff's phenomenon

As Uhthoff 's phenomenon in the original sense one occurring after exercise temporary worsening of visual acuity in multiple sclerosis (MS ) is called. The phenomenon was created by the ophthalmologist Wilhelm Uhthoff (1853-1927) first described. Is based on a reversible blocking of the conductivity of the pre-damaged optic nerve due to an increase in body temperature.

As Uhthoff 's phenomenon in a broader sense the transient worsening of neurological symptoms of MS with an increase in body temperature (eg, fever, hot baths or sauna ) is called. It affects more than 80% of those affected by MS. The cause also a temperature-induced degradation of the conductivity of demyelinated axons is assumed. The Uhthoff phenomenon can also occur with other demyelinating diseases.

In fact, a so-called hot bath test in the 20th century was broad diagnostic use. As in individual cases, however, triggered by the increase in body temperature transient worsening of symptoms was not reversible, this test is now obsolete.

Because it must be distinguished from a disease thrust, the Uhthoff phenomenon remains clinically significant today. A worsening of the condition of MS patients due to heat or strain is also referred to as a pseudo- push.

Therapy

The prophylaxis is to prevent significant physical effort as well as the avoidance of circumstances that increase the body temperature (eg, sauna, hot baths, high ambient temperatures, etc.). The symptomatic complaints can also be limited by wearing cooling garments such as cooling vests, cooling hoods or cooling jackets. Also already persistent limitations can be favorably influenced by cooling.

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