Urobilinogen
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Urobilinogen is a breakdown product of bilirubin and is one of the bile pigments ( Bilane ). It is formed by bacteria of bilirubin, which is discharged from the bile into the intestine. 20% of the urobilinogen is reabsorbed, supplied via the portal vein of the liver, further degraded and partly excreted in the urine. Urobilinogen is an intermediate in the formation of urobilins.
The normal Urobilinogenkonzentration in urine ranges from 0.1 to 1.8 mg / dl ( 1.7 to 30 micromol / L ) concentrations > 2.0 mg / dl (34 micromol / L ) are considered pathological.
Urobilinogen in urine does not occur when no bilirubin reach the intestine. A Urobilinogenurie may, but need not be accompanied by a bilirubinuria. Urobilinogen is excreted in the urine increased when the liver is bypassed, is overloaded or functionally limited. Urobilinogen is through the kidneys.
Urobilinogen is increasingly detected in urine at:
- Hemolytic anemia (increased breakdown of red blood cells)
- Constipation, intestinal inflammation
- Infections of the biliary tract
- Acute and chronic liver inflammation
- Toxic liver damage, liver tumors
- Congestion ( in heart failure )
Proof
Urobilinogen is detectable by a clutch of urobilinogen of stabilized diazonium salt lightly with urine test strips. The practical detection limit is 0.4 mg / dl, values below 1 mg / dl are considered normal. This test is not overly accurate enough for a medical evaluation but completely out. It can help to detect liver damage and to distinguish between different causes of jaundice ( bilirubin increase).