Urocortin

Urocortin hot more peptides consisting of approximately 40 amino acids, which are produced in mammals. You have 45 % sequence homology to corticotropin releasing factor (CRF ). In humans three Urocortine are known to bind to the CRF receptors, are neurohormones.

The human Urocortine hot urocortin (40 amino acids), urocortin -2 ( 41 amino acids) and urocortin -3 ( 38 amino acids). Your precursor proteins are encoded by different genes ( UCN, UCN2, UCN3 ).

In 1995, Vaughan and co-workers found in the Edinger - Westphal nucleus of the rat brain a CRF related " urotensin -like molecule" and called it urocortin. In the following years it was realized that urocortin is widespread in mammalian organisms and as well as CRF agonist binds to CRF receptors, albeit with a higher affinity to CRF2 receptors. Therefore, it is assumed that the natural ligand of the urocortin CRF2 receptor.

Urocortin stimulates the same G- proteins such as CRF and therefore has a similar pharmacology to.