VGF

  • OMIM: 602186
  • MGI: 1343180

VGF is a peptide, the " VGF nerve growth factor inducible protein" as, " Neuroendocrine specific protein " or " VGF protein" is well known and has been discovered in 1985. It consists of 593 amino acids and is controlled by the tissue hormone NGF. The Molar mass of 65 kDa. VGF and its fragments play a role in the energy budget, food intake and mood. VGF released by neurons of the central and peripheral nervous system, as well as cells of the adrenal gland and the beta cells of the endocrine portion of the pancreas.

Literature and sources

  • Van den Pol AN, et al. VGF expression in the brain, J Comp Neurol. 1994 September 15; 347 ( 3) :455 -69
  • Smita Thakker - Varia et al.: The Neuropeptide VGF Produces Antidepressant -Like Behavioral Effects and Enhances proliferation in the hippocampus, Journal of Neuroscience, November 7, 2007, 27 (45 ) :12156 - 12167
  • Angelo L. Garcia: A prohormone convertase cleavage site within a predicted alpha -helix mediates sorting of the neuronal and endocrine polypeptide VGF into the Regulated Secretory Pathway, J. Biol Chem, Vol 280, Issue 50, 41595-41608, December 16, 2005, doi:. 10.1074/jbc.M509122200
  • Hahm S, et al.: VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro- opiomelanocortin -and neuropeptide Y -containing arcuate neurons in response to fasting. J Neurosci 2002, 22:6929-6938.
  • Neuropeptide
Human Genome Organisation Mouse Genome Informatics Euarchontoglires Entrez Ensembl UniProt National Center for Biotechnology Information Bioenergetics Digital Object Identifier
802834
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