10-Deacetylbaccatin

Colorless solid

Fixed

231-236 ° C

Insoluble in water, soluble in methanol, supercritical carbon dioxide

Template: Infobox chemical / molecular formula search available

10 - deacetyl baccatin III is a representative of Deacetylbaccatine, a group of closely related natural products that are derived from yew (Taxus ). It is a starting material for the manufacture of anticancer drugs.

History and habitat

10 - deacetyl taxol is as much as the Antitiumormittel to the naturally occurring taxanes. Taxol ( paclitaxel) and other representatives of this class inhibit cell growth or cell division and are therefore applied in the fight against cancer. The high interest in 10 - deacetyl baccatin III is due to produce taxol and other taxanes in commercial quantities in the difficulties. Taxol can be gained from the bark of the Pacific yew tree (Taxus brevifolia ), a shrub -like tree, which is native to the north-west of Canada and the U.S. and is listed there in scattered populations. Because the Pacific yew tree grows very slowly, the bark is thick enough to win from her Taxol only at about 100 year old trees. The content of taxol in the bark is only about 0.01-0.02 %. For the production of 1 g of taxol - this represents only half of the amount that is needed in a typical course of treatment for a patient - the bark of three mature trees is therefore necessary. The extraction of taxol from the bark of the Pacific yew tree leads to the destruction of the tree, alone for the first clinical trials with taxol had to be felled 13,000 trees. Theoretical energy calculations showed that the commercialization of Taxol would have led only yew bark as a source in a few years to completely eradicate the yew. 10 - deacetyl other hand, is a more sustainable source of taxane - based drug: It is found in higher amounts of up to 0.2 % in other species of yew (for example in the European yew ) and is included not only in the cortex, but can be obtained while preserving the yew portfolio from renewable needles and branches.

Representation and use

10 - deacetyl is obtained from the needles and branches of various species of yew by extraction. The connection can be implemented in a few steps to taxol. And the anti-tumor agent is cabazitaxel from 10-deacetylbaccatin III semi- synthetically.

Proof

To demonstrate the connection can, inter alia, Immunological detection methods are used.