2-Pyrrolidone

  • Pyrrolidin- 2-one
  • Azolidine -2-one
  • 2-pyrrolidone
  • 4- Aminobuttersäurelactam
  • γ -lactam
  • Butyrolactam

Colorless to pale yellow solid

Fixed

1.12 g · cm -3

25 ° C.

245 ° C.

4 Pa ( 20 ° C)

  • Soluble in water
  • Poorly in cyclohexane ( 12.3 g · l-1 at 22 ° C)

1.4853

Attention

Template: Infobox chemical / molecular formula search available

γ - butyrolactam, short γ -lactam or butyrolactam, is a chemical compound from the group of lactams. Butyrolactam, the lactam of the γ -aminobutyric acid ( GABA), an inhibitory neurotransmitter, and it can be converted by hydrolysis to GABA.

Production

For the preparation of the reaction of γ - butyrolactam butyrolactone can be used with ammonia at elevated temperature.

Properties

Butyrolactam is a deliquescent at room temperature solid which melts at 25 ° C.

Use

Butyrolactam is an intermediate in the preparation of polyvinylpyrrolidone. For this purpose, γ - lactone is first reacted with ammonia at 230 ° C to butyrolactam, which reacts in a subsequent step with elemental potassium and acetylene at 100 ° C to N -vinylpyrrolidone.

Furthermore, it may be used for the synthesis of NMP. For this purpose, it is placed at 300 ° C over aluminum oxide with methanol to the reaction.

In industrial processes, it is used as a high-boiling polar solvent.

Various derivatives of butyrolactam which are called Racetame (eg piracetam, aniracetam, oxiracetam, Pramiracetam and others) are used in medicine as a nootropic.

CAS registry number PubChem Vapor pressure Chemical element Integrated Authority File
12187
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