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- 250: First general persecution of Christians in the Roman Empire due to the victim Edict of Decius, that although Christianity does not prohibit, but it depreciates as a sect.
- 250: The Franks are first mentioned in Roman historiography.
- June 1st half 251: Battle of Abrittus, Emperor Decius falls in battle against the Goths; his successor will Trebonianus Gallus.
- 257: Great persecution of Christians in Rome by Valerian.
- 259 The Alamanni overcome a broad front the Upper Germanic Limes - Raetian whose crew was greatly reduced because of the internal conflict between Roman Emperor Gallienus and the usurper Postumus.