3'-Phosphoadenosine-5'-phosphosulfate

Fixed

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3'- phosphoadenosine -5'- phosphosulfate or PAPS is an adenosine compound.

Adenosine is phosphorylated to the case of the 3 ' and at the 5 - position and the phosphate group at the 5'- position in addition connected to a sulfate group. Therefore, the compound is also known under the name of sulfuric acid activated respectively activated sulfate. The sulfate group can be transferred with the help of enzymes ( sulfotransferases ) on suitable substrates. In this way, PAPS plays an important role in the biosynthesis of natural products such as carrageenan or heparin, as well as in the detoxification of foreign substances by the body ( xenobiotics ). By sulphating the aqueous solubility is increased, so that these conjugates can be known more easily excreted by the kidney.

The substance is present in the physiological medium pH dependent mostly in the anionic form ( see formula ) before. However, the molecular formula, molecular weight and CAS Registry number listed refer to the charge-neutral, so fully protonated form.