3-hydroxyanthranilate 3,4-dioxygenase

3- Hydroxyanthranilat -3 ,4- dioxygenase ( 3HAO ) ( Gen: HAAO ) is called the one enzyme that oxidizes the 3- Hydroxyanthranilat to 2 - amino-3- carboxymuconat -semialdehyde. This reaction step, part of the degradation pathway of the amino acid tryptophan, but the reaction product is the starting material for biosynthesis of nicotinic acid and NAD. 3HAO is found in many bacteria, fungi and animals. In humans, it is mainly produced in the liver.

Inhibition of 3HAO with 4-chloro -3- hydroxyanthranilat reduced the accumulation of quinolinate in newly spinal cord injured mice and improved the neurological symptoms.

Catalyzed reaction

O2 H2O

3- Hydroxyanthranilat is oxidized to a semialdehyde, which spontaneously rearranges to quinolinate.

Human Genome Organisation Digital Object Identifier
13281
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