3-(Trifluoromethyl)aniline

• Aniline ( trifluoromethyl ) - 2
• α, α, α -trifluoro -o-toluidine

• Aniline ( trifluoromethyl ) - 3
• α, α, α -trifluoro -m-toluidine

• Aniline ( trifluoromethyl ) - 4
• α, α, α -trifluoro -p-toluidine

Aminobenzotrifluorides are chemical compounds selected from the group consisting of halogenated benzene derivatives, which are derived from benzotrifluoride. Depending on the position of the Trifluoride to the amino group, there are three isomers.

Production and representation

3- aminobenzotrifluoride from benzotrifluoride can be synthesized by nitration with nitric acid to form 3- nitrobenzotrifluoride, and its subsequent reduction (catalytic hydrogenation). This results in a lesser extent the other two isomers. By initially chlorinating benzotrifluoride (which must be later reversed by catalytic hydrogenation ), thereby blocking the 3-position, the yield of 2- aminobenzotrifluoride can be greatly increased.

Properties

Aminobenzotrifluorides are yellow to brown, slightly volatile liquids with an unpleasant odor, which are soluble in water. They decompose at a temperature above 5 ° C, with hydrogen fluoride, carbon monoxide, carbon dioxide and nitrous gases.

Use

3- aminobenzotrifluoride is used as an intermediate in the preparation of plant protection agent (such as fluometuron and flurochloridone ), and pharmaceuticals (e.g., flufenamic acid ). 4- aminobenzotrifluoride also serves as an intermediate in the manufacture of drugs (eg leflunomide or teriflunomide ).

Safety

The vapors of aminobenzotrifluorides can form ( 55-85 ° C, ignition temperature 600 ° C flash point) with air to form an explosive mixture.