4-Hydroxynonenal

  • 4 -HNE
  • HNE
  • Trans-4- hydroxy-2- nonenal
  • (E )-4- hydroxy-2- nonenal
  • (S) - (E )-4- hydroxy-2- nonenal
  • (RS) - (E )-4- hydroxy-2- nonenal

Liquid

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4- hydroxynonenal, is a more reactive α, β - unsaturated aldehyde, the lipid peroxidation of the polyunsaturated fatty acids ( polyunsaturated fatty acids Sheet - PUFAs) arises. In this process, in turn, be modified proteins under conditions of oxidative stress, ie damaged.

History

4 -HNE was characterized by Hermann Esterbauer and has since published a number of publications on this substance.

Biological Significance

4 -HNE is associated with various diseases linked, especially Alzheimer's, cancer and atherosclerosis.

Isomerism

4- hydroxynonenal contains an asymmetrically substituted carbon-carbon double bond and in addition a stereogenic center. Thus there are four isomeric compounds:

  • (S, R )-4- hydroxynonenal,
  • (S, S )-4- hydroxynonenal,
  • ( Z, R )-4- hydroxynonenal and
  • ( Z, S )-4- hydroxynonenal.
Stereochemistry CAS registry number PubChem Dangerous Substances Directive (67/548/EEC) Lipidperoxidation
14139
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