Acetanisole

Colorless, sweet-smelling boards

Fixed

1.08 g · cm -3

38 ° C.

263 ° C

6.44 Pa (20 ° C)

Poorly in water ( 2.47 g · l-1 at 25 ° C ), well in ethanol

Attention

Template: Infobox chemical / molecular formula search available

4- methoxyacetophenone, p- Acetylanisol or short Acetanisol, is a methyl ketone of anisole. The structure is derived from that of the anisole and additionally has an acetyl group at the para -position to the methoxy group. It has a pleasant, sweet odor, similar to that of hawthorn flowers or anisaldehyde.

Occurrence and use

In nature, it comes in castoreum, a glandular secretion of the beaver, before. It is a minor component of drugs and is used as a fragrance, for example in deodorant.

Representation

Acetanisol synthesized from anisole and acetyl chloride in a Friedel -Crafts acylation:

An environmentally friendly alternative to using aluminum trichloride as catalyst for the Friedel -Crafts acylation constitutes catalysis with zeolites

Properties

Acetanisol is a colorless, crystalline substance with sweet scent. The crystals melt even at low heat (about 38 ° C).

Toxicology

In studies with rats and rabbits LD50 values ​​of 1720 mg · kg -1 ( oral) and> 5000 mg · kg -1 ( percutaneous) were determined. In studies in 1985 with humans and mice, it produced an increase in heart rate and blood pressure in humans and in mice drowsiness and muscle weakness.