Achlorhydria

As achlorhydria a lack of stomach acid is referred to in the gastric juice.

At the absolute achlorhydria acid production can not be provoked by the administration of pentagastrin ( = pentagastrinrefraktäre Anazididät ) also in the relative chemical or achlorhydria it is missing only apparent, for example, at a Pylorusinsuffizienz with her reflux alkaline small intestine content.

An absolute achlorhydria may occur in type-A gastritis ( corpus gastritis, autoimmune gastritis ), as this leads to a loss of parietal cells of the gastric mucosa. Also, removal of the stomach or vagotomy leads to achlorhydria. Furthermore, it is an early symptom of pernicious anemia and in addition to watery diarrhea and hypokalemia also one of the symptoms of the WDHA syndrome. Even with fractional examination of the stomach contents is a constant lack of hydrochloric acid is thereby proved.

As gastric acid enhances the absorption of iron, leads to a achlorhydria and thus to malabsorption of iron deficiency (see, iron metabolism ).