Agenesis of the corpus callosum

The corpus callosum agenesis ( the corpus callosum ) is a congenital malformation of the brain that is characterized in that the connection between the right and left hemisphere of the brain, the corpus callosum is missing or underdeveloped. For a partial corpus callosum agenesis only a portion of the bar is missing. If the beam on the other hand severed surgically, it is not a corpus callosum agenesis, but split brain.

Frequency

In general, the Corpus callosum agenesis occurs sporadically, however, the occasional occurrence in siblings on a role of genetic factors towards (X- Chromosomal or autosomal recessive inheritance ) and it is considered here from a feature ownership in 10% of siblings. Generally, the incidence of 3:1.000 7:1.000 to.

Diagnosis

The corpus callosum agenesis is congenital and manifests itself in early childhood. Prenatal diagnosis is possible. With more than 70 syndromes, the corpus callosum is one of the typical features ( = syndromatische Corpus callosum agenesis ). Four out of 50 children have a chromosomal feature: Very common features in terms of the chromosomes 8, 13 chromosomes or chromosomes can be found 18 such as Patau syndrome ( trisomy 13), Edwards syndrome ( trisomy 18) or triploidy here. Even in people with chromosomal aberrations of chromosomes 3 times a bar defect was detected.

Forecast

The range of possible development of children with corpus callosum agenesis is quite large. It depends, among other things, whether the malformation individually or whether it is characteristic of a particular disability, which in turn is accompanied by other symptoms that affect the development. Depending on the development prognosis for children with emotional corpus callosum in the context of the substantial absence of a specific symptom to severe physical and cognitive disabilities (even with, for example, epilepsy, ataxia, or disturbance of thermoregulation ).