Albendazole

Methyl-5- ( propylthio) -2- benzimidazole carbamate

• P02CA03
• QP52AC11

Anthelmintic

Microtubule inhibitor

208-210 ° C

Poorly in water and alcohol, good in anhydrous formic acid, poor in dichloromethane

Risk

Template: Infobox chemical / molecular formula search available

Albendazole is a drug, specifically a newer benzimidazole carbamate, which is used worldwide as an anthelmintic. It is a white or slightly yellowish powder, which is administered, for example, prepared as a suspension. It is preferably living against various living in the gut and tissue roundworms ( nematodes) as well as in organs (eg, brain, liver, lungs) larval forms ( fins) of certain tapeworms, used, for example, the pig tapeworm, of the fox tapeworm and the tripartite dog tapeworm.

Albendazole is the drug of choice in the treatment of cysticercosis and alveolar echinococcosis and cystic human, either in addition to or in combination with surgical methods, or, if the latter are contraindicated, as sole therapeutic measure in the form of a long-term treatment. Albendazole can also be used in the treatment of microsporidia (for example Encephalitozoonose ).

It causes all benzimidazoles as starvation and leaving the animals primarily by failure of glucose uptake and prevents the formation of fertile eggs by disturbed formation of the spindle apparatus and metabolic disorder.

Albendazole is administered orally. The use during pregnancy is contraindicated.

Albendazole is probably poorly absorbed from the digestive tract due to its poor water solubility. Taken in conjunction with fatty meals, the consumption increases by about a factor of 5 is already largely metabolized in the first liver passage to albendazole and immersed himself in practice not in the blood plasma on. The effect against living tissue worms is mainly attributed to the secondary material. He keeps up with a half-life of 8.5 hours in the blood and is then broken down mainly in the bile.

Albendazole was first discovered as a derivative thiabendazole for veterinary medicine and introduced in 1981 for the treatment of worm infections.

Trade names

Eskazole (A, D, EU and Others ), Valbazen ad us.vet. (D, CH), Zentel (CH)