Alessandro Lualdi studied in Milan and Rome, the subjects of philosophy and Catholic theology. He received in 1880 the sacrament of Holy Orders, and then worked as a parish pastor in Milan. From 1890 to 1894 he taught at the Milan Seminary, from 1894 to 1904 he worked as a lecturer in Rome. 1899 awarded in Pope Leo XIII. the title of Pontifical secret chamberlain. Pope Pius X appointed him in 1904 as Archbishop of Palermo. The bishop ordained Alessandro Cardinal Rampolla Mariano Lualdi.
On April 15, 1907 Alessandro Lualdi was taken as cardinal priest with the titular church of Santi Andrea e Gregorio al Monte Celio in the College of Cardinals. He took both 1914 and 1922 part of the conclave. In 1926 he was sent by Pope Pius XI. as papal legate in celebration of the eight hundredth anniversary of Saint Agatha to Catania. Alessandro Lualdi died on November 12, 1927 in Palermo, and was buried in the Maria Santissima Assunta Cathedral.