Allan C. Spradling
Charles Allan Spradling (* 1949 in Kalamazoo, Michigan) is an American embryologist and geneticist at the Carnegie Institution for Science in Baltimore, Maryland.
Life
Spradling initially studied mathematics and physics and graduated from the University of Chicago, a BS in physics, before turning to biology. In 1975, he earned at the Massachusetts Institute of Technology ( MIT), a Ph.D. with a thesis on polytene chromosomes and heat shock proteins in Drosophila. As a postdoctoral fellow, he worked at Indiana University in Bloomington.
1980 Spradling went to the Carnegie Institution in Baltimore, Maryland, where he was director of the local establishment of Embryology in 1994. Since 1988, Spradling research in addition to the Howard Hughes Medical Institute ( HHMI ). In addition, he has been a professor ( adjunct professor ) of biology at Johns Hopkins University and of genetics at Johns Hopkins University School of Medicine, both also in Baltimore.
Work
In Bloomington Spradling could have provided evidence that protein - coding genes may be subject to amplification. At the Carnegie Institution in 1982, he developed together with Gerry Rubin a method ( coupling to a transposon ) to inject DNA into the genome of Drosophila. Subsequently he was able to identify cis elements that are involved in the regulation and amplification of genes. Also with Rubin founded Spradling 1991, the Drosophila genome project, which was completed in 2000 with the sequencing of the entire genome. Spradling examined stem cells in their normal tissue environment and described for the first time that stem cells each even look for a " niche ", a micro- environment that they need to maintain themselves and their intended function.
Recent work Spradlings deal with epithelial stem cells and the development of eggs.