At the age of eight, she started performing in theater productions. Her film debut was in 2002 with the lead role in the comedy Real Women Have Curves, for which she was nominated in 2003 for the Young Artist Award. This was followed by guest appearances in television series such as CSI: Vegas and more film roles in A for 4 and Lords of Dogtown.
From 2006 until 2010, she played the title role in the series Ugly Betty, the U.S. version of Yo soy Betty, la fea, for which she became the first Latina Golden Globe Award won for Best Actor in a TV Series / Comedy. A year later she received at the Emmy Awards 2007, the award for Best Actress in a Comedy Series and a Screen Actors Guild Awards 2007 Award for Best Actress in a Television Series - Comedy.
In addition to her acting career, she studied International Relations at the University of Southern California.
In June 2011 she married actor Ryan Piers Williams.
- 2002: Real Women Have Curves (Real Women Have Curves )
- 2002: Touched by an Angel ( Touched by an Angel)
- 2002: rhythm in the blood ( Gotta Kick It Up )
- 2004: CSI: Crime Scene Investigation ( CSI: Crime Scene Investigation, TV Series, Episode 5x03 Harvest )
- 2005: Lords of Dogtown ( Lords of Dogtown )
- 2005: A 4 ( The Sisterhood of the Traveling Pants )
- 2006-2010: Ugly Betty ( Ugly Betty, TV Series, 85 episodes)
- 2007: La Luna Misma
- 2008: A 4 - the Traveling Pants ( The Sisterhood of the Traveling Pants 2)
- 2008: Tinker Bell
- 2010: Train Your Dragon ( How to Train Your Dragon, Voice of Astrid )
- 2010: Our Family Wedding
- 2011: The Good Wife ( The Good Wife, TV series, 3 episodes)
- 2012: End of Watch
- 2002 - Sundance Film Festival: Special Jury Prize as Ana Garcia in Real Women Have Curves
- 2006 - Imagen Award: Best Actress as Carmen Lowell in A for 4
- 2007 - Teen Choice Awards: Choice TV Breakout as Betty Suarez in Ugly Betty
- 2007 - Screen Actors Guild Awards: Outstanding Lead Actress in a Comedy Series as Betty Suarez in Ugly Betty
- 2007 - Satellite Awards: Best Actress in a Musical or Comedy Series as Betty Suarez in Ugly Betty
- 2007 - Imagen Award: Creative Achievement Award
- 2007 - Imagen Award: Best Actress in a Series as Betty Suarez in Ugly Betty
- 2007 - Golden Globe Award: Best Actress in a Musical or Comedy Series as Betty Suarez in Ugly Betty
- 2007 - Emmy Awards: Best Actress in a Comedy Series ( Primetime ) as Betty Suarez in Ugly Betty
- 2007 - ALMA Awards: Best Actress in a TV series, miniseries or TV movie as Betty Suarez in Ugly Betty
- 2008 - NAACP Image Awards: Best Actress in a Comedy Series as Betty Suarez in Ugly Betty
- 2010 - Imagen Award: Best Actress in a TV series as Betty Suarez in Ugly Betty