Aminohippuric acid

• 2 - ( (4- aminobenzoyl ) amino ) acetic acid (IUPAC)
• 4- aminohippuric
• Paraaminohippuric acid
• PAH

Fixed

199-202 ° C

Template: Infobox chemical / molecular formula search available

P- aminohippuric acid, also paraaminohippuric acid or 4- amino hippuric acid, is a chemical compound derived from the hippuric acid. It finds particular application as a diagnostic tool for the investigation of renal function application. As a condensation product of p- aminobenzoic acid and the amino acid glycine can occur as a metabolite in the human body.

Synthesis

P- aminohippuric acid can be represented by the condensation of p- amino benzoic acid with glycine. When using dehydrating agents this happens faster, but unclean. A more elegant method of preparation is the nitration of hippuric acid to the p- Nitrohippursäure followed by reduction with a selective reducing agent to the p- aminohippuric acid.

Use

To study the renal function and the calculation of renal blood flow p- aminohippuric acid is administered as an infusion. As p- aminohippuric acid almost completely by the kidneys by glomerular filtration (20-30%) and tubular secretion (70%) is excreted, its corresponding clearance, the PAH clearance, the renal plasma flow. This is used to calculate the renal blood flow.