Ampoule

The vial is a container for pharmaceuticals for parenteral administration are usually ( injection), cosmetics and other substances. There are different types and forms of containers called vial. As the material glass is mostly used, rare plastic. The material used for the production can be colorless or colored ( eg brown glass) to ensure its as light better durability of light-sensitive content.

Uses

Ampoules types

  • With an annular breaking point around the ampoule neck. This ring may be a refractive branded enamel ring, which generates a stress in the glass, which allows a clean cancel the skewer. Alternatively it can be etched into the glass of refractive ring.
  • OPC ampoule: One-Point -Cut vials usually have a pre-scored, marked point or a notch on the neck of the ampoule. The ampoule head can be canceled by pressing the thumb against the labeled point.
  • Capsule Similarly shaped glass containers: In two places the glass is very thin. With a tool (glass mandrel - spur ) the glass can be pierced at these locations.
  • Plastic containers

Opening ampoules

Request to glass ampoules

For the preparation of ampoules conventional household glass can not be used because it has a low resistance to water, that is, there may be substances through the aqueous solution from the glass dissolved (hydrolysis) that contaminate the solution or undesirable change would.

Therefore, the European Pharmacopoeia different glass types according to their hydrolytic class and sets the application for which they are suitable.

  • Class I: Highest hydrolytic resistance, such as borosilicate glass. Suitable for vials, which are used more than once.
  • Class II: High hydrolytic resistance. Suitable for ampoules, which are intended only for a single use.
  • Class III: Mean hydrolytic resistance, such as soda-lime silicate glass. Conditionally suitable for ampoules: only for powders or non-aqueous solutions.
  • Class IV: Low hydrolytic resistance, such as soda-lime glass (commercial household glass ). Not suitable for ampoules.

Most colorless glasses are used for light-sensitive substances brown glass used.

Labeling of ampoules

The labeling of ampoules is especially important for drugs. The vials can be labeled:

  • With an adhesive label
  • With a printing of paint, such as a screen printing method

In addition to the part of a marking applied with color rings is used for example, to avoid confusion during production, before the label is affixed, to be avoided.

Swell

  • Rudolf Voigt, Alfred Fahr: Pharmaceutical Technology. German Apotheker Verlag, 2006 ( 9 edition ), ISBN 3,769,226,496th
  • European Pharmacopoeia Ph. Eur 5.5. German Apotheker Verlag, February 2007, ISBN 3769240634 ( The latest valid version can be found online in English., European Pharmacopoeia Online).
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