Anaplerotic reactions

Anaplerotic ( ancient Greek fill ἃνά - πληρόω, complete make ) reactions are the Citric Acid Cycle supplying legal metabolic pathways. Through them all losses of intermediates of the citric acid cycle, caused by diversion of these intermediates for biosynthesis, balanced. In contrast, there are cataplerotische reactions.

An example of an anaplerotic reaction is the synthesis of oxaloacetate from pyruvate and carbon dioxide catalyzed by pyruvate carboxylase:

Pyruvate CO2 H2O ATP → oxaloacetate ADP Pi 2 H

The energy required for the reaction is supplied by the hydrolysis of ATP to ADP and phosphate.

This fill-in is required in mammals, since they do not possess the enzyme for the conversion of acetyl-CoA into oxaloacetate or to another intermediate. More anaplerotic metabolic pathways are part of the amino acid metabolism: where eg aspartate or glutamate by oxidative deamination to the intermediates oxaloacetate and α -ketoglutarate are implemented.