Guardado is the Mexican whiz of 2005. Was only in August he gave the age of 20 be Erstligadebüt at his home club CD Atlas of Guadalajara and immediately became firmly integrated into the team. 26 Matches graduated from the offensive man in his first year.
In July of 2007 he moved abroad when he made the jump to Europe and signed at Deportivo La Coruna, which paid a transfer fee of € 7 million. This was at the time the highest transfer fee ever paid for a Mexican.
On 28 May 2012, announced that Guardado changes to the new season for FC Valencia.
On January 30, 2014 Guardado moved to the end of the 2013/14 season on loan to Bundesliga Bayer 04 Leverkusen. In addition, there is a purchase option.
División after only a few months in the Mexican Primera, he stood on 14 December 2005 for the first time for the Mexican national team on the court, without having previously played in a national youth selection. In preparing for the 2006 World Cup he was used several times and became the youngest player in his country he was in the World Cup squad in Mexico.
- Deportivo's Footballer of the Year 2007/ 08