Antimycin A
3- methylbutanoic acid 3 - ( (3 - ( formylamino ) - 2-hydroxybenzoyl ) amino )-8- hexyl- 2,6-dimethyl- 4 ,9- dioxo- 1,5- dioxonan -7 - yl ester
Colorless crystals
Fixed
149-150 ° C
- Insoluble in water
- Insoluble in ethanol, acetone and diethyl ether
Risk
- 2.9 mg · kg -1 ( LD50, duck, oral)
- 1.8 mg · kg -1 ( LD50, guinea pig, oral)
- 55 mg · kg -1 ( LD50, mouse, oral)
- 28 mg · kg -1 ( LD50, rat, oral)
Template: Infobox chemical / molecular formula search available
Antimycin A, more antimycin A1, is an antibiotic from Streptomyces and an inhibitor of the respiratory chain. It binds to the complex III, and thus blocks the transmission of electrons from the coenzyme Q cytochrome c. The components of the respiratory chain, which are the site of action of antimycin A in complex III, remain reduced. All components behind it, remain oxidized. Thus, consumption of oxygen in the complex IV, and the synthesis of ATP in the complex V is inhibited.
Operation
Antimycin A binds to the Qi site in the cytochrome bc1 complex, thus preventing electron transfer from heme b H to ubiquinone.