Apolipoprotein A1

  • OMIM: 107680
  • UniProt: P02647
  • MGI: 88049

Apolipoprotein A1 ( ApoA1 ) is the protein in the blood of vertebrates that binds HDL particles of cholesterol and fatty acids. These particles are transported to the liver and reduced the cholesterol there or excreted ( reverse cholesterol transport ). ApoA1 is essential cofactor for the enzyme LCAT which contributes to the same pathway. It is also part of chylomicrons. Human APOA1 is expressed in the liver and in the small intestine. Mutations in APOA1 can ApoA1 hereditary deficiency, and this lead to HDL deficiency or FAP polyneuropathy type III.

ApoA1 one of the apolipoproteins, a set of transport proteins.

As part of the SPAP complex, activates the ApoA1 motility of sperm. It interacts with ApoA1 and clusterin binding protein. In Alzheimer's patients apoA1 binds to beta -amyloid and prevents damage caused by this protein. Infusions of ApoA1 be taken into clinical trials as a potential anti-atherosclerotic agents into consideration. Atherosclerotic patients show elevated levels of ApoA1 nitrate.

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