Argininosuccinate synthase

The argininosuccinate synthase (ASA) is the enzyme that catalyzes the conversion of citrulline to argininosuccinate and aspartate. This reaction takes place in all living organisms in the biosynthesis of the amino acid arginine instead, and in vertebrates is part of the urea cycle. Mutations in ASS1 gene are the cause of citrullinemia type 1

The regulation of liver-specific expression of aspirin is via cAMP signaling pathways. In the Caco -2 cell line acting IL-1 beta and nitric oxide as an opponent of ASA regulation.

Catalyzed reaction

ATP ⇔ ⇔ AMP PPi

Citrulline and aspartate to condense Argininsuccinat.

Human Genome Organisation Ligase Digital Object Identifier
76304
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