Atipamezole

4 - (2 -ethyl-2 ,3-dihydro -1H -inden- 2-yl) -1H-imidazole

QV03AB90

α2 -adrenoceptor antagonist

• 212.29 g · mol -1 ( atipamezole )
• 248.75 g · mol -1 ( · atipamezole hydrochloride)

211-215 ° C ( atipamezole hydrochloride · )

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Atipamezole is an α2 -adrenoceptor antagonist and is used in veterinary medicine to reverse the sedative and analgesic effects of α2 -adrenoceptor agonists ( medetomidine, detomidine, dexmedetomidine, xylazine ). A small effect unfolds the drug on α1 -adrenoceptors. It is excreted by the kidneys.

Atipamezole has an approximately 100 times higher specificity to α2 -adrenoceptors as yohimbine. It can also be used as an antidote for an overdose of amitraz. The drug is administered intravenously or intramuscularly.