Azilsartan

1-[(2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl)methyl]-2-ethoxy-1H-benzimidazol-7-carboxylsäure-(5-methyl-2-oxo-1,3-dioxol-4-yl)methylester

• C25H20N4O5 ( Azilsartan )
• C30H24N4O8 ( Azilsartanmedoxomil )
• C30H23N4O8K ( Azilsartanmedoxomil - potassium)

C09CA09

• 456.46 g · mol -1 ( Azilsartan )
• 568.53 g · mol -1 ( Azilsartanmedoxomil )

Fixed

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Azilsartan is a synthetic chemical compound from the group of benzimidazoles, which acts as an angiotensin II receptor antagonist and is therefore used as a drug for the treatment of essential hypertension in adults.

• 2.1 Mechanism of action ( pharmacodynamics )

Clinical information

Type and duration of application

Therapy with Azilsartan can be used as monotherapy or in combination therapy with other antihypertensive agents. The starting dose 40 mg once daily is recommended. If by any adequate blood pressure control is possible, the dose may be increased to a maximum of 80 mg once daily.

Contraindications ( contraindications)

Like other sartans is also Azilsartan in the second and third trimester of pregnancy is contraindicated, the use in the first trimester is not recommended.

Pharmacological properties

Mechanism of action ( pharmacodynamics )

The active ingredient as the potassium salt of its prodrugs Azilsartanmedoxomil ( an ester of the carboxylic acid Azilsartan, trade name Edarbi ) is used, which is rapidly after oral administration converted into the active form, Azilsartan. The mechanism of action corresponds to that of the other AT1 antagonists and is described in detail in the article about the group of active ingredients sartans.