B-cell activating factor

BAFF (B cell activating factor of the TNF family) also known as BLyS (B Lymphocyte Stimulator), or TALL-1 or ZTNF4 is a cytokine of the TNF superfamily, and an important survival factor of B cells, predominantly of neutrophils, monocytes and macrophages is produced in mammals. Knockout mice having a deficiency for Baff exhibit impaired B -cell development, wherein the development in the transitional, (T1) is blocked stage. These mice have no mature follicular B cells and barely marginal zone B cells. The few mature B cells, which do occur, expressing surface markers CD21 and CD23 do not. B1 cells develop, however, in the Baff -deficient animals normally, the early cells of the B lymphoid lineage in the bone marrow are also not affected. Baff Baff is bound by the receptor and TACI. BCMA binds Baff contrast, only weak. Increased Baff levels are associated with autoimmune diseases such as SLE. A neutralizing antibody against Baff ( belimumab ) is currently being tested as a therapeutic agent against SLE.

There is an isoform that lacks the membrane anchor, and therefore in the cytosol is free to move. It is caused by post-translational modification and contains 152 amino acids.

Swell

  • Fabienne Mackay, William A. Figgett, Damien Saulep, Melanie Lepage, Margaret L. Hibbs: B -cell stage and context -dependent requirements for survival signal from BAFF and the B -cell receptor. In: Immunological Reviews. 237, No. 1, 2010, pp. 205-225, doi: 10.1111/j.1600-065X.2010.00944.x.
Human Genome Organisation TNFRSF13C Protein isoform Digital Object Identifier Science (journal)
97156
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