BAAT

• OMIM: 602938
• UniProt: Q14032

Bile acid -CoA: amino acid N- acyltransferase (BAT) is the enzyme in animals, which catalyzes the final step in the biosynthesis of bile salts. In this case, cholic acid or deoxycholic acid CoA is transferred to amino acids, these are in humans of up to 95 % glycine or taurine. The reaction occurs ( hepatocytes) in the peroxisomes of the liver cells. By the amidation, the Emulgationsfähigkeit the compounds increased dramatically, therefore lipids and vitamins can be absorbed better. Mutations in the BAAT gene are the cause of the rare Hypercholanämie ( FHCA ).

Catalyzed reactions

H2N - CH2 -COO- ⇒ CoA -SH

Choloyl -CoA reacts with glycinate to glycocholate and CoA -SH. Equivalently, the reaction takes place with Taurat to taurocholate.