Basophil granulocyte

Basophils are a population of leukocytes ( white blood cells ) in the blood. You have intracellular granules, which contain, among other histamine and heparin. The differential blood count, they account for a small proportion of 0-1 %. Growth factors for the basophils include interleukin-3, interleukin -5 and GM-CSF. There is evidence for reciprocal control of maturation between basophils and eosinophils. For example, to suppress TGF -beta ( transforming growth factor a ) in the presence of interleukin- 3, the differentiation of eosinophils and promotes the basophils. They have a receptor for immunoglobulin E ( IgE), which is why it is assumed that they play a role in the immune defense of the host against parasites.

If their receptors are cross -linked by bound IgE allergens, degranulate basophils and pour toxic mediators, such as histamine and PAF ( platelet aggregation causes ), from. Eosinophils, basophils and mast cells can interact with each other and enhance mutual degranulation yet.

The activation of immune cells that have receptors for IgE, as lead to the immediate allergic reaction for example hay fever. Systemic activation of these cells (ie, the activation throughout the body ) can lead to anaphylactic shock.

To a proliferation of basophils ( basophilia ) in the blood may in myeloproliferative diseases, especially chronic myeloid leukemia, come.