Bcl-2-associated X protein
- OMIM: 600040
- UniProt: Q07812
Bax, a protein in vertebrates, which acts as co- factor of the tumor suppressor protein p53. Bax gene belongs to the Bcl-2 gene family. Bax is induced by p53 and accelerates the induction of apoptosis. Low Bax distribution correlates with poor prognosis in oral cavity carcinomas.
Swell
- Toshiyuki Miyashita and John C. Reed (1995). Tumor Suppressor p53 Is a Direct Transcriptional Activator of the Human bax genes. Cell, 80, 293-299. PMID 7834749
- Oltvai, Z., Milliman, C., and Korsmeyer, SJ (1993). Bcl -2 Heterodimerizes in vivo with a Conserved Homolog, Bax, did Accelerates Programmed Cell Death. Cell, 74, 609-619. PMID 8358790