- OMIM: 151430
- MGI: 88138
Bcl -2 ( Abbreviation for. B- cell lymphoma 2) is a protein and the prototype of the same protein family, which in the regulation of programmed cell death (apoptosis ) play a role. Some members of the family promote apoptosis, while others prevent it. It is believed that at least a portion of these proteins perform their function in that they regulate the release of cytochrome c from the mitochondria. This has the cell death. Also likely are involved in the activation of procaspases, some of these proteins.
Because the correct induction of apoptosis is very important to have a mutation in the genes of these proteins can have serious consequences. Therefore, this protein family is also considered the human proto- oncogene.
About activations lead to the proliferation of the tissue and thus tumors. The protein was first isolated in the B- cell lymphoma (BCL ).
Proteins belong to this family:
- Anti- apoptotic: Bcl-2
- Bcl -xL
- Bcl- xS