Benzidine

• 4 - (4 -aminophenyl ) aniline (IUPAC)
• 4,4 '- diaminobiphenyl
• 1-amino- 4-(4 -aminophenyl ) benzene
• 4,4 '- Bianilin
• Paradiaminobiphenyl
• C. I. 37225

Yellow prisms

Fixed

1.25 g · cm -3

127 ° C.

401.7 ° C ( 987 hPa)

• Very poor in water ( 400 mg · l-1 at 12 ° C ), ethanol, acetone and diethyl ether
• Soluble in alkalis and glacial acetic acid

Risk

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Benzidine is a derivative of biphenyl. There is a safe for humans carcinogenic substance. After contact with this material often develop after a multi-year latency bladder tumors. Benzidine can be easily absorbed through the skin but also through inhalation of vapor or dust. Benzidine is blood damaging and debilitating to the bone marrow. After years of exposure may lead to methemoglobin formation and anemia. Heaped occur bladder and urothelial carcinoma.

Formerly known as benzidine assay for the detection of blood in the stool, for example, has been applied in medicine. It is used together with hydrogen peroxide to form a blue color by oxidation and benzidine. Also in forensics this study was common. Meanwhile, Blood on less dangerous and more specific methods, such as the modified guaiacol test after Greegor ( Haemoccult ) is demonstrated.

Benzidine remains a basic element of some important toxicological azo dyes of double diazotized benzidine and derived from benzidine compounds such as 3,3 '- dimethylbenzidine, 3,3'- dimethoxybenzidine or 3,3 ' -dichlorobenzidine. The substance is not released from textiles or leather articles which may come a long time with the human skin directly in contact are (Appendix 1 of the Consumer Goods Ordinance ) after reductive cleavage of azo groups.

Representation

Benzidine can be made from hydrazobenzene by the benzidine rearrangement.