Boronic acid

Boron acids include boric acid derivatives in which a hydroxy group is substituted by a Organylgruppe. They belong to the most organoboron compounds. Furthermore, it is in boronic acids Lewis acids.

A unique feature of boronic acids is that they can form reversible covalent complexes with saccharides, amino acids and hydroxamic acids. The pKa values ​​of the boronic acids are about 9 However, you can also take the form of tetrahedral borate complexes occur whose pK at ~ 7 lies.

Typical applications of boronic acids are the links to saccharides for fluorescent detection or selective transport through membranes. Boronic acids are used in organic chemistry to combine organic substances by means of Suzuki coupling with each other. In addition, they are used for transmetalation.

Bortezomib is a boronic acid -containing drug, which is used in chemotherapy.