Buchwald–Hartwig amination

The Buchwald- Hartwig coupling is a response from the field of organic chemistry. It was developed simultaneously by the groups of John F. Hartwig and Stephen L. Buchwald in 1994. Describes the reaction of the palladium-catalyzed coupling of an aryl halide or triflate with a primary or secondary amine in the presence of a base.

As a catalyst, palladium complexes are used (M = Pd), wherein the ligand (L ) is usually phosphines. And tris (dibenzylideneacetone) dipalladium ( 0) is used as a catalyst. Suitable bases usually bis ( trimethylsilyl ) amides or tert- butanolates be used.