CA 19-9

The Carbohydrate antigen 19-9 (CA 19-9 ) is a used as a tumor marker in oncology glycoprotein, whose half-life is 4-8 days. His laboratory chemical detection occurs (depending on the assay standard value < 37-40 kU / l) by immunoassay. The maximum achievable diagnostic sensitivity is 95 %. The presence of CA 19-9 is tied to the sponsorship of the Lewis blood group. People who possess the blood group Lewis negative ( a-/b- ), do not express CA 19-9.

Differential Diagnosis

The highest sensitivity, the CA 19-9 in pancreatic cancer ( in pancreatic cancer with a diameter of <3 cm of the marker in about 50 % of cases is positive and at a tumor diameter of> 3 cm in about 85-90 %). At the height of the pancreatic tumor marker correlated with the tumor size.

When following other tumors, there are occasional increase of CA 19-9 levels in serum:

  • Cholangiocarcinoma ( ≈ 70%)
  • Gastric carcinoma ( ≈ 40%)
  • Colorectal cancer ( ≈ 35%)

Non- malignant diseases that can lead to an increase in CA 19-9 levels:

  • Pancreatitis
  • Diseases of the biliary tract
  • Liver disease
  • Nicotine abuse

Clinical Application

The measurement of CA 19-9 is used for tumors (if its level was elevated before treatment) for the treatment and follow-up.

  • Gastroenterology
  • Tumor markers
  • Abbreviation
Tumormarker Stomach cancer
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