Calmodulin

Calmodulin ( CaM ) is a calcium -binding regulatory protein, which is found highly conserved in all eukaryotes. Calmodulin plays an important role in second messenger systems. It belongs to the group of EF-hand proteins. As the structure of the EF-hand calcium -binding region is known, which forms a typical helix-turn -helix structure. This family of proteins, among others, to the Include troponin C, parvalbumin and Calbin is one of the two major calcium-binding protein families and additionally there is the group of annexins. Calmodulin is bound to find in human smooth muscle to actin, where it regulates the contraction.

There are three known alleles which code for the identical protein.

Objectives of the active Ca2 / calmodulin complex for example, the CaM -dependent kinase ( CaMK ), adenylyl cyclase, which Myosinleichtkettenkinase ( MLCK ), the phosphatase calcineurin and endothelial nitric oxide synthase ( eNOS).

Some substances, such as the W-7 inhibit the protein as calmodulin inhibitors, by transporting the calcium necessary for enzyme activation from the cell.

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