Prominin is the first identified member of a new type of membrane proteins in animal cells (specifically, a glycoprotein ). It has an unusual design with five membrane -penetrating areas and two large protruding from the membrane extracellular loops. It was found in stem cells, epithelial cells and Nonepithelzellen, and in photoreceptor cells of the retina. Prominin interacts with membrane cholesterol and is a marker for a cholesterol derived lipid called raft. With a mutation in the protein responsible for the production of the human gene (the protein will be reduced ) is usually occurs retinal degeneration.


  • Proceedings of the National Academy of Sciences of the United States of America, Vol 94, No. 23 (Nov. 11, 1997), pp. 12425-12430
  • Hereditary disease - associated protein