Cefotaxime

• (6R, 7R ) -3 - ( acetyloxymethyl ) - 7 - (( 2 - (2 -amino-1 ,3-thiazol -4-yl ) - 2 (Z)- methoxyiminoacetyl ) amino ) - 8 -oxo -5- thia -1 -azabicyclo [ 4.2.0] oct-2 -ene-2 ​​-carboxylic acid

• 63527-52-6
• 64485-93-4 (sodium salt)

J01DD01

β -lactam antibiotics ( Cephalosporin 3rd generation)

Risk

20,000 mg · kg -1 ( LD50, rat, oral)

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Cefotaxime is an antibiotic from the group of third generation cephalosporins. After the grouping of the Paul- Ehrlich- Institute, it belongs to the group 3a of parenteral cephalosporins.

The bactericidal effect is, as with other β -lactam antibiotics by inhibiting bacterial cell wall synthesis.

Spectrum of activity

In contrast to the cephalosporins of group 1 (eg, cefazolin ) Cefotaxime is more effective against Gram-negative bacteria, such as gonorrhea, meningococcal and Enterobacteriaceae. However, cefotaxime is compared to the other members of his group 3a ( ceftriaxone, ceftizoxime, Cefmenoxim ) relatively poorly effective against pseudomonas.

Cefotaxime blocked not only the division of bacteria, including cyanobacteria, but also the division of cyanelles, the photosynthetic organelles of Glaucocystaceae, and the chloroplasts of Physcomitrella moss. However, on the division of plastids of the highly developed vascular plants such as tomatoes in it have no effect. This is an indication that at higher plants show took place through evolutionary changes in the Plastidteilung β -lactam antibiotics generally chloroplasts no longer effective.

Indications

Cefotaxime and its broad spectrum suitable for the calculated initial therapy of severe, life-threatening infections such as pneumonia, sepsis or meningitis. The effect of gaps to be closed, especially in combination with an aminoglycoside or Aclyaminopenicillin. In addition, cefotaxime is suitable for the treatment of neuroborreliosis.

Trade names

Claforan (D, A ), various generics (D, A)