Celiprolol

  • (RS )-N' -(3- acetyl-4- (3 - ( (1,1- dimethylethyl) amino) - 2 - hydroxypropoxy ) phenyl )-N, N- diethylurea
  • (±) -N' -(3- acetyl-4- (3 - ( (1,1- dimethylethyl) amino) - 2 - hydroxypropoxy ) phenyl )-N, N- diethylurea
  • Rac -N' -(3- acetyl-4- (3 - ( (1,1- dimethylethyl) amino) - 2 - hydroxypropoxy ) phenyl )-N, N- diethylurea
  • DL -N' -(3- acetyl-4- (3 - ( (1,1- dimethylethyl) amino) - 2 - hydroxypropoxy ) phenyl )-N, N- diethylurea
  • Celiprololum
  • C20H33N3O4 ( celiprolol )
  • C20H33N3O4 · HCl ( Celiprolol · hydrochloride)
  • 56980-93-9
  • 57470-78-7 ( Celiprolol · hydrochloride)

C07AB08

Beta blocker

Selective blockade of β1 - receptors

  • 379.49 g · mol -1 ( celiprolol )
  • 415.95 g.mol -1 ( · celiprolol hydrochloride)

2157 mg · kg -1 ( LD50, rat, oral)

Template: Infobox chemical / molecular formula search available

Celiprolol, a drug from the group of β -adrenergic receptor blocker, is used to treat high blood pressure and coronary heart disease.

Clinical information

Celiprolol is a medium long-acting antagonist at β1 -adrenoceptors and a partial agonist at β2 -adrenoceptors, which has a half -life of four to twelve hours and a duration of action of up to one day. The bioavailability of celiprolol is 50%. As a β2 - adrenoceptor agonist celiprolol leads active vasodilation of peripheral vessels. Excretion is mainly via the kidneys. The application resulting from a severe renal impairment is contraindicated.

Other Information

The peculiarity of celiprolol and some other beta-blockers ( acebutolol, oxprenolol and pindolol ) is the intrinsic sympathomimetic activity (ISA, see Intrinsic activity).

Trade names

Selectol (D, A, CH)

With chlorthalidone: Selecturon (A)

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System Active ingredient Receptor antagonist Partialagonist
171971
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